Signals mediating cleavage of intercellular adhesion molecule-1

Signals mediating cleavage of intercellular adhesion molecule-1.

ICAM-1, a membrane-bound receptor, is released as soluble ICAM-1 in inflammatory diseases. To delineate mechanisms regulating ICAM-1 cleavage, studies were performed in endothelial cells (EC), human embryonic kidney (HEK)-293 cells transfected with wild-type (WT) ICAM-1, and ICAM-1 containing single tyrosine-to-alanine substitutions (Y474A, Y476A, and Y485A) in the cytoplasmic region. Tyrosine ...

Intercellular Adhesion Molecule (ICAM)-1,

Intercellular Adhesion Molecule-1 Expression

Intercellular Adhesion Molecule-1 Deficiency

Intercellular Adhesion Molecule-1 and Leukocyte